Estudo descobre que as células imunológicas do cérebro de pessoas com doença de Alzheimer estavam em estado pré-inflamatório

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Estudo descobre que as células imunológicas do cérebro de pessoas com doença de Alzheimer estavam em estado pré-inflamatório

Autópsias revelam novas descobertas sobre o Alzheimer

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Autópsias revelam diferenças no comportamento das células imunitárias em cérebros com Alzheimer, abrindo caminho para possíveis novos tratamentos

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A pesquisa da Universidade de Washington identificou diferenças nas microglias, células imunológicas do cérebro, em pessoas com Alzheimer, que frequentemente estão em estado pré-inflamatório

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As microglias mantêm o cérebro saudável, eliminando resíduos e preservando sua função normal, mas em casos de Alzheimer, sua resposta exagerada pode causar inflamação e morte celular

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Apesar dos medicamentos anti-inflamatórios para Alzheimer, os ensaios clínicos não mostraram efeitos significativos, motivando a investigação mais aprofundada

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A pesquisa usou amostras de autópsias cerebrais para estudar o gene em 12 pessoas com Alzheimer e 10 saudáveis, identificando 10 clusters diferentes de microglias

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Um dos tipos de microglia observados em pessoas com Alzheimer estava associado a genes relacionados à inflamação e morte celular

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As microglias em estado pré-inflamatório nas pessoas com Alzheimer tendem a produzir moléculas inflamatórias, contribuindo para a progressão da doença

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A capacidade das microglias de mudar de tipo ao longo do tempo sugere que sua análise pode ajudar a compreender melhor o Alzheimer

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Os aglomerados específicos de microglias identificados podem ser alvos para novos tratamentos, avançando na compreensão e tratamento do Alzheimer

Quer saber mais sobre as novas descobertas sobre o Alzheimer?

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