Além de fatores externos como má alimentação, doença está relacionada à ação de enzima no organismo; entenda o motivo

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Além de fatores externos como má alimentação, doença está relacionada à ação de enzima no organismo; entenda o motivo

Novo fator associado ao diabetes tipo 2

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A diabetes tipo 2 está em ascensão devido a dietas ricas em alimentos processados e gordurosos, mas fatores biológicos também desempenham um papel crucial na doença.

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Cientistas da Case Western Reserve University identificaram uma enzima, SCAN, que interfere na ação da insulina, contribuindo diretamente para o desenvolvimento da diabetes tipo 2.

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A enzima SCAN liga o óxido nítrico às proteínas, incluindo o receptor da insulina, afetando sua ação no organismo e potencialmente levando ao diabetes tipo 2.

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Óxido nítrico é essencial para várias funções corporais, mas seu mecanismo de ação ainda é pouco compreendido, impulsionando pesquisas sobre sua relação com doenças como a diabetes.

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Segundo Jonathan Stamler, bloquear a enzima SCAN pode prevenir diabetes tipo 2, oferecendo um novo alvo terapêutico para combater a doença.

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Aumentada atividade da enzima SCAN foi observada em pacientes diabéticos e camundongos diabéticos, sugerindo que seu bloqueio poderia proteger contra a diabetes tipo 2.

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A pesquisa indica que o bloqueio da SCAN pode também ter implicações para outras doenças ligadas ao óxido nítrico, como Alzheimer, câncer e insuficiência cardíaca.

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a ligação excessiva de óxido nítrico a proteínas-chave pode acelerar ou causar várias doenças, tornando as enzimas que realizam essa ligação focos importantes para a medicina.

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A descoberta da função da SCAN abre novas possibilidades para tratamentos direcionados, oferecendo esperança para o desenvolvimento de terapias eficazes contra a diabetes tipo 2 e outras doenças.

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