O fabricante YourChoice Therapeutics iniciou esta semana o teste de fase I de sua pílula anticoncepcional masculina

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O fabricante YourChoice Therapeutics iniciou esta semana o teste de fase I de sua pílula anticoncepcional masculina

Primeiro anticoncepcional masculino sem hormônios

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Homens britânicos estão testando o primeiro anticoncepcional masculino sem hormônios, o YCT-529.

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Diferente das opções anteriores, este inibe o receptor alfa do ácido retinóico para bloquear a produção de espermatozoides.

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Ao contrário dos métodos anteriores que visavam suprimir a testosterona, o YCT-529 abre portas para uma responsabilidade mais igualitária na contracepção

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Estudos prévios demonstraram que a privação de vitamina A levou à infertilidade em camundongos e outros animais, inspirando a abordagem deste novo anticoncepcional.

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O YCT529 atua inibindo seletivamente o receptor α do ácido retinóico, essencial na formação dos espermatozoides. Sua potência é notável, superando outras moléculas em quase 500 vezes.

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Em testes com ratos machos, o contraceptivo atingiu 99% de eficácia na prevenção da gravidez. Surpreendentemente, após a interrupção do uso, os ratos recuperaram a fertilidade

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A reversibilidade total e rápida do efeito contraceptivo, sem efeitos adversos, é um ponto positivo para o YCT529, tornando-o uma promissora opção contraceptiva masculina.

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Embora os resultados sejam promissores, a chegada dessa pílula contraceptiva masculina ao mercado ainda não tem uma data certa. O ensaio clínico deve ser concluído em junho de 2024.

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A conclusão do ensaio clínico será crucial para determinar a segurança e eficácia do YCT529 em humanos, o que pode levar à sua disponibilidade.

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